Endocrine Abstracts

Background: The majority of complications in transfusion dependent thallasemic and with sickle cell anemia patients are due to iron overload. This is responsible for the beginning of haemosiderosis, clinical symptoms and dysfunction of important systems, specially after the 2nd decade of life. The increase of the iron accumulation is caused by hemolysis, high iron absorbance and mainly by transfusion treatment. The appearance of diabetes mellitus depends on the significance an...

Background: Diabetes mellitus (DM) is related to hypercoagulability.The predisposition for thrombosis disorders is caused by increased accumulation of platelets, by high concentrations of prothrombotic factors and by the reduced concentration and activity of the inhibitor factors. Abnormalities of coagulation inhibitors have been reported in many studies on diabetes over the last years, but unfortunately, the results have often appeared contradictory.</p...

Background: The diagnosis of hypoparathyroidism, a clinical situation characterised by reduced production of parathyroid hormone despite the low calcium level, depends on patient’s anamnesis, clinical aspect and the biochemical parameters.Thalassaemia, an inherited autosomal recessive blood disease, caused by the reduced capacity of erythroblasts to synthesize one of the chains that build up hemoglobine. The combination of transfusion and chelation ...

Introduction: The decline of renal function is closely associated to increased parathyroid hormone secretion, resulting to secondary hyperparathyroidism because of: 1) hypocalcemia; 2) hyperphosphatemia; 3) reduced activity of calcitriol; 4) skeletal resistance to the calcemic action of parathyroid hormone (PTH) and 5) reduced secretion of the calcium-sensing receptor (CaSR) in the parathyroid glands.The retention of phosphorus is considered to take an i...

Irisin is an adipomyokine produced during physical activity and implicated in the browning of adipose tissue. Existing evidence suggests an inverse relationship between irisin plasma levels and adverse metabolic outcomes; however, the exact impact of diet on irisin levels remains unclear. We aimed to assess the effects of two dietary patterns, Christian Orthodox fasting (OF) and 16:8 time-restricted eating (TRE), on irisin concentrations among overweight, metabolically healthy...

Background: Data on the effects of different dietary patterns on free 25-hydroxyvitamin D [25(OH)D] and vitamin D binding protein (VDBP) concentrations are scarce. Our objective was to prospectively assess changes over time in these parameters and possible correlations with diet composition among overweight adults who followed a pescatarian Orthodox intermittent fasting (OF) regimen and controls who followed a low-fat 12:12 diet for 7 weeks.Methods: Tota...

Background: Previous research has demonstrated positive effects of Orthodox fasting (OF) and time restricted eating (TRE) on body weight (BW). However, little is known about the late, metabolic effects of the two diets.Methods: 29 overweight adults followed a hypocaloric diet based on OF. A hypocaloric, TRE plan (eating between 08:00 to 16:00 h) was followed by 16 BW-matched participants. Anthropometric, glycemic and inflammation markers and serum lipids...

Background: Infection with the human immunodeficiency virus (HIV) predisposes to endocrine disorders, manifesting as a metabolic phenotype that affects the entire adipose-musculoskeletal unit (AMS). The present cross-sectional study aimed to investigate differences in irisin and adiponectin concentrations between people living with HIV and healthy controls, as well as to explore potential correlations between the levels of the aforementioned adipokines and markers of calcium h...

BackgroundOrthodox religious fasting (OF) is a variation of the classical Mediterranean Diet during which meat and other animal products are restricted, whereas fish are occasionally and sea food are always allowed. The aim of this prospective study was to assess sex-specific differences in changes of lipid concentrations in a cohort of metabolically healthy adults following OF and investigate a potential role of vitamin D status in mediating these varia...